PPI network

Protein interaction and microRNA network analysis in osteoarthritis meniscal cells

M. Wang, Liu, C., Zhang, Y., Hao, Y., Zhang, X., and Zhang, Y. M., Protein interaction and microRNA network analysis in osteoarthritis meniscal cells, vol. 12, pp. 738-746, 2013.

Osteoarthritis is the most common form of arthritis among elderly adults. Herein, we performed protein-protein interaction (PPI) and miRNA network analysis to evaluate the global correlation between miRNA regulation and the PPI network in human osteoarthritis. Our results showed that desmoplakin (DSP), cystatin A (CSTA), calmodulin 1, tyrosine kinase endothelial, insulin-like growth factor 1 (IGF-1), IGF-binding protein 7 (IGFBP7), syndecan 1 (SDC1), ephrin type-A receptor 4, and PDZ and LIM domain protein 1 were associated with osteoarthritis.

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