POU1F1 gene

Analysis of POU1F1 gene DdeI polymorphism in Chinese goats

M. J. Li, Zhang, C. M., Lan, X. Y., Fang, X. T., Lei, C. Z., Chen, H., Li, M. J., Zhang, C. M., Lan, X. Y., Fang, X. T., Lei, C. Z., and Chen, H., “Analysis of POU1F1 gene DdeI polymorphism in Chinese goats”, vol. 15, p. -, 2016.

As a member of the POU-domain family, the POU1F1 is a positive regulator for growth hormone, prolactin and thyroid-stimulating hormone b, by binding to target DNA promoters as a dimer in mammals. This study described the polymorphisms at the goat POU1F1-DdeI locus and analyzed the distribution of alleles in 15 indigenous Chinese goat breeds. The PCR-RFLP analysis showed a predominance of the D1D1 genotype and the D1 allele, with average frequencies of 0.550 and 0.790, respectively, irrespective of goat utility type.

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