Postoperative progression

Association of NPP1 polymorphism with postoperative progression of ossification of the posterior longitudinal ligament in Chinese patients

Z. He, Zhu, H., Ding, L., Xiao, H., Chen, D., and Xue, F., Association of NPP1 polymorphism with postoperative progression of ossification of the posterior longitudinal ligament in Chinese patients, vol. 12, pp. 4648-4655, 2013.

Ossification of the posterior longitudinal ligament (OPLL) is a condition of the spine that can cause paralysis by compressing the spinal cord. The aim of this study was to evaluate the possible role of nucleotide pyrophosphatase phosphodiesterase 1 gene (NPP1) polymorphism in the etiology and pathology of the OPLL in Chinese patients. DNA from patients with OPLL (N = 95) and without OPLL (N = 90) were genotyped for 4 NPP1 single-nucleotide polymorphisms (SNPs): A533C, C973T, IVS15-14T→C, and IVS20-11delT.

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