Postmenopausal women

MTHFR C677T polymorphism and osteoporotic fracture in postmenopausal women: a meta-analysis

J. Z. Guan, Wu, M., Xiao, Y. Z., Zhou, J. S., and Wang, Z. D., MTHFR C677T polymorphism and osteoporotic fracture in postmenopausal women: a meta-analysis, vol. 13, pp. 7356-7364, 2014.

Numerous studies have evaluated the association between MTHFR C677T polymorphism and osteoporotic fracture risk in postmenopausal women. However, the results have been inconsistent. We performed a meta-analysis of the association between MTHFR C677T polymorphism and osteoporotic fracture risk in postmenopausal women. Only seven case-control studies were retrieved, with a total of 4258 patients and 3454 healthy controls.

Association analysis of vitamin D receptor gene polymorphisms and bone mineral density in postmenopausal Mexican-Mestizo women

A. González-Mercado, Sánchez-López, J. Y., Regla-Nava, J. A., Gámez-Nava, J. I., González-López, L., Duran-Gonzalez, J., Celis, A., Perea-Díaz, F. J., Salazar-Páramo, M., and Ibarra, B., Association analysis of vitamin D receptor gene polymorphisms and bone mineral density in postmenopausal Mexican-Mestizo women, vol. 12, pp. 2755-2763, 2013.

We investigated associations between vitamin D receptor (VDR) gene polymorphisms, FokI T>C (rs2228570), BsmI G>A (rs1544410), ApaI G>T (rs7975232), and TaqI T>C (rs731236), with bone mineral density (BMD) in postmenopausal Mexican-Mestizo women. Three hundred and twenty postmenopausal women participated, who were classified according to World Health Organization criteria as non-osteoporotic (Non-OP; N = 88), osteopenic (Opn; N = 144), and osteoporotic (OP; N = 88).

Association between single nucleotide polymorphisms of the osteoprotegerin gene and postmenopausal osteoporosis in Chinese women

J. F. Song, Jing, Z. Z., Hu, W., and Su, Y. X., Association between single nucleotide polymorphisms of the osteoprotegerin gene and postmenopausal osteoporosis in Chinese women, vol. 12, pp. 3279-3285, 2013.

Osteoporosis is an important and common complex health problem, particularly in postmenopausal women. It is characterized by a reduction in bone mineral density (BMD) and a deterioration of bone microarchitecture with a consequent increase of fracture risk. The osteoprotegerin (OPG) gene is considered to play an important role in the pathogenesis of osteoporosis. We analyzed SNPs of the OPG gene and associations between these polymorphisms and BMD in 399 Chinese postmenopausal women.

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