Postmenopausal osteoporosis

HLA-A gene polymorphisms contribute to osteoporosis susceptibility in postmenopausal Han Chinese women

S. M. Li, Guo, H., Yang, H. J., Lv, M. Q., and Zhou, D. X., HLA-A gene polymorphisms contribute to osteoporosis susceptibility in postmenopausal Han Chinese women, vol. 14, pp. 10322-10330, 2015.

Osteoporosis is a common disease characterized by low bone mineral density, deterioration in bone microarchitecture, and increased fracture risk and is more prevalent in postmenopausal women. HLA is a complex gene family; previous studies have shown that it plays an important role in the pathogenesis of osteoporosis among Japanese and Greek populations. Prompted by these findings, this study was designed to explore the associations between HLA-A gene polymorphisms and postmenopausal osteoporosis in the Han Chinese population.

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