Polymorphisms

Lack of association between potential prothrombotic genetic risk factors and arterial and venous thrombosis

F. C. G. Evangelista, Rios, D. R. A., Ribeiro, D. D., Carvalho, M. G., Dusse, L. M. S., Fernandes, A. P., and Sabino, A. P., Lack of association between potential prothrombotic genetic risk factors and arterial and venous thrombosis, vol. 14, pp. 9585-9594, 2015.

Recent studies have shown an association between thrombosis and factor VII (FVII), tissue factor (TF), and angiotensin-converting enzyme (ACE). This suggests that individuals with FVII-402 G/A, FVII-401 G/T, TF+5466 A/G, and ACE-287 insertion/deletion (I/D) polymorphisms present an increased risk of venous thrombosis, heart disease, and ischemic stroke compared with controls. In this study, we investigated the frequencies of these polymorphisms and their association with arterial and venous thrombosis.

Thymidylate synthase and methylenetetrahy­drofolate reductase gene polymorphisms and gastric cancer susceptibility in a population of Northern Brazil

M. D. Araújo, Borges, B. N., Rodrigues-Antunes, S., Burbano, R. M. R., and Harada, M. L., Thymidylate synthase and methylenetetrahy­drofolate reductase gene polymorphisms and gastric cancer susceptibility in a population of Northern Brazil, vol. 14. pp. 10001-10006, 2015.

The folate metabolic pathway, which is involved in DNA synthesis and methylation, is associated with individual susceptibility to several diseases, including gastric tumors. In this study, we investigated four polymorphisms [thymidylate synthase enhancer region, single nucleotide polymorphism thymidylate synthase 5' (TS5'), TS3' untranslated region, and methylenetetrahydrofolate reductase (MTHFR) 677C> T] in 2 genes related to the folate pathway, TS and MTHFR, and their possible association with the risk gastric cancer development in a population from Pará state, Brazil.

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