Polymorphisms

An let-7 KRAS rs712 polymorphism increases hepatocellular carcinoma risk

D. Xiong, Song, Y. P., Xiong, W., and Liang, Y. D., An let-7 KRAS rs712 polymorphism increases hepatocellular carcinoma risk, vol. 14, pp. 14050-14055, 2015.

KRAS, also known as V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, acts as an intracellular signal transducer. The oncogenic KRAS mutation is an essential step in the development of many types of human cancers, including hepatocellular carcinoma. Here we aimed to investigate the relationship between KRAS rs712 polymorphisms and hepatocellular carcinoma susceptibility. Five-hundred-and-fourteen participants were enrolled in a case-control study (262 cases and 252 normal subjects).

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