Polymorphism

Lack of an association between matrix metalloproteinase polymorphisms and coronary heart disease in a Han Chinese population

C. M. Wang, Ye, H. D., Li, Y. R., Hong, Q. X., Tang, L. L., Zhou, A. N., Xu, M. Q., and Duan, S. W., Lack of an association between matrix metalloproteinase polymorphisms and coronary heart disease in a Han Chinese population, vol. 14, pp. 12254-12261, 2015.

Coronary heart disease (CHD) has become a leading cause of human deaths worldwide. Recent studied showed that polymorphisms of the matrix metalloproteinase (MMP) genes played important roles in extracellular matrix remodeling and contribute to the pathogenesis of vascular diseases. Here, we investigated whether these MMP gene polymorphisms were associated with CHD in Han Chinese. Our case-control study was involved with 1509 unrelated individuals, including 777 CHD cases and 732 controls.

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