Polymorphism

Association between a functional genetic polymorphism (rs2230199) and age-related macular degeneration risk: a meta-analysis

M. X. Zhang, Zhao, X. F., Ren, Y. C., Geng, T. T., Yang, H., Feng, T., Jin, T. B., and Chen, C., Association between a functional genetic polymorphism (rs2230199) and age-related macular degeneration risk: a meta-analysis, vol. 14, pp. 12567-12576, 2015.

The association between the rs2230199 C>G single nucleotide polymorphism (SNP) in complement component 3 and age-related macular degeneration (AMD) risk has been examined extensively but the results are not consistent among studies. The aim of this study was to perform a meta-analysis of all available studies on this SNP in relation to AMD. The comprehensive databases of PubMed, Medline, Web of Knowledge, CNKI, and Google Scholar were searched for case-control studies investigating the association between the rs2230199 polymorphism and AMD susceptibility.

Genomic selection for slaughter age in pigs using the Cox frailty model

V. S. Santos, S. Filho, M., Resende, M. D. V., Azevedo, C. F., Lopes, P. S., Guimarães, S. E. F., Glória, L. S., and Silva, F. F., Genomic selection for slaughter age in pigs using the Cox frailty model, vol. 14, pp. 12616-12627, 2015.

The aim of this study was to compare genomic selection methodologies using a linear mixed model and the Cox survival model. We used data from an F2 population of pigs, in which the response variable was the time in days from birth to the culling of the animal and the covariates were 238 markers [237 single nucleotide polymorphism (SNP) plus the halothane gene]. The data were corrected for fixed effects, and the accuracy of the method was determined based on the correlation of the ranks of predicted genomic breeding values (GBVs) in both models with the corrected phenotypic values.

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