Polymorphism

Association between PAI-1 polymorphisms and plasma PAI-1 level with sepsis in severely burned patients

Y. F. Chi, Chai, J. K., Yu, Y. M., Luo, H. M., Zhang, Q. X., and Feng, R., Association between PAI-1 polymorphisms and plasma PAI-1 level with sepsis in severely burned patients, vol. 14, pp. 10081-10086, 2015.

We investigated the association between plasminogen activator inhibitor-1 (PAI-1) polymorphisms and plasma PAI-1 level with sepsis in severely burned patients. A total of 182 patients with burn areas lager than 30% of the body surface area were enrolled in this study. Peripheral blood samples were obtained from 103 patients with sepsis (sepsis group) and 79 patients without sepsis (control group). An allele-specific polymerase chain reaction assay was used to determine PAI-1 polymorphism 4G/5G distribution.

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