Polymorphism

Correlation between polymorphisms in the IL-17A and IL-17F genes and development of coronary artery disease

G. Y. Geng, Liu, H. L., Zhao, Y. J., Wu, L., Mao, L., and Ba, N., Correlation between polymorphisms in the IL-17A and IL-17F genes and development of coronary artery disease, vol. 14, pp. 11488-11494, 2015.

A case-control study was conducted to investigate the association between genetic variants of IL-17A rs2275913 and IL-17F rs763780 and the development of coronary artery disease (CAD) in a Chinese population. A total of 306 individuals with CAD and 306 unaffected individuals were enrolled from the Zhengzhou People’s Hospital between May 2012 and May 2014. The IL-17A rs2275913 and IL-17F rs763780 genes were genotyped by polymerase chain reaction combined with a restriction fragment length polymorphism (PCR-RFLP).

Genetic variability of genes involved in DNA repair influence treatment outcome in osteosarcoma

M. J. Wang, Zhu, Y., Guo, X. J., and Tian, Z. Z., Genetic variability of genes involved in DNA repair influence treatment outcome in osteosarcoma, vol. 14, pp. 11652-11657, 2015.

We conducted a perspective study to investigate the role of ERCC1 (rs11615), ERCC2 (rs13181 and rs1799793), ERCC4 (rs1800067), and ERCC5 (rs17655) in NER pathway in the prognosis of osteosarcoma patients. In total, 146 osteosarcoma patients were recruited between 2008 and 2013. ERCC1 rs11615, ERCC2 rs13181 and rs1799793, ERCC4 rs1800067, and ERCC5 rs17655 gene polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism assay.

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