Polymorphism

Role of IL-17 gene polymorphisms in the susceptibility to gastric cancer

W. T. Qi, Gao, J. L., and Zhang, S. S., Role of IL-17 gene polymorphisms in the susceptibility to gastric cancer, vol. 14, pp. 13364-13369, 2015.

We conducted a study to investigate the role of three IL-17 gene single nucleotide polymorphisms (SNP) (rs2275913G>A, rs3748067C>T, and rs763780 T>C) in the development of gastric cancer. A total of 252 patients with gastric cancer and 252 control subjects were collected between May 2012 and May 2014. The SNP genotyping of IL-17A rs2275913G>A and rs3748067C>T and IL-17F rs763780 T>C was performed using the Sequenom MassARRAY platform (Sequenom, San Diego, CA, USA) according to the manufacturer instructions.

Rapid microsatellite development in Gekko japonicus using sequenced restriction-site associated DNA markers

L. Wei, Shao, W. W., Zhou, H. B., Ping, J., Li, L. M., and Zhang, Y. P., Rapid microsatellite development in Gekko japonicus using sequenced restriction-site associated DNA markers, vol. 14, pp. 14119-14122, 2015.

Twelve polymorphic microsatellite loci were isolated in the Japanese gecko, Gekko japonicus. We genotyped one population from Wenzhou, Zhejiang Province, China (N = 36). The mean number of observed alleles per locus was 7.3 (range 4 to 13). Observed and expected heterozygosity values ranged from 0.200 to 0.944 and from 0.395 to 0.797, respectively. One locus (GJ20) showed significant departure from Hardy-Weinberg equilibrium; no linkage disequilibrium was found between any two loci.

Vascular endothelial growth factor -634 G/C polymorphism and risk of cancer: an updated meta-analysis

J. Y. Ban, Shin, J. I., and Oh, C. - H., Vascular endothelial growth factor -634 G/C polymorphism and risk of cancer: an updated meta-analysis, vol. 14, pp. 13906-13914, 2015.

The association between vascular endothelial growth factor (VEGF) gene polymorphisms and risk of cancer has been investigated in several studies published previously; however, the individual results are inconclusive. Therefore, we performed a meta-analysis to establish evidence for an association between the VEGF -634 G/C polymorphism and risk of cancer. We searched PubMed, Medline, and Korean Studies Information Service System databases and identified 29 case-control studies, containing data of 25,324 individuals, for this meta-analysis.

Lack of association between the hOGG1 gene Ser326Cys polymorphism and gastric cancer risk: evidence from a case-control study and a meta-analysis

W. G. Hu, Pan, R. J., Cai, W., Wang, Z. T., and Zhu, Z. G., Lack of association between the hOGG1 gene Ser326Cys polymorphism and gastric cancer risk: evidence from a case-control study and a meta-analysis, vol. 14, pp. 14670-14679, 2015.

The association between the human 8-oxoguanine glycosylase 1 (hOGG1) gene Ser326Cys polymorphism (rs1052133) and gastric cancer has been widely evaluated, yet a definitive answer to whether this association exists is lacking. We first conducted a case-control study to assess this association in a large Han Chinese population, and then performed a meta-analysis to further address this issue. This case-control study involved 448 patients clinically diagnosed with gastric cancer and 372 cancer-free control individuals from China.

Impact of common SNPs in VEGF gene on the susceptibility of osteosarcoma

G. L. Hu, Ma, G., and Ming, J. H., Impact of common SNPs in VEGF gene on the susceptibility of osteosarcoma, vol. 14, pp. 14561-14566, 2015.

We conducted a case-control study to assess the role of vascular endothelial growth factor (VEGF) -634G/C, +936C/T, and +1612G/A genetic variations in the development of osteosarcoma in a Chinese population. This hospital-based case-control study examined 130 patients with osteosarcoma and 130 age- and gender-matched healthy controls from March 2011 and March 2013. Polymerase chain reaction-restriction fragment length polymorphism was applied to assess the VEGF -634G/C, +936C/T, and +1612G/A gene polymorphisms.

Vascular endothelial growth factor gene polymorphisms and psoriasis susceptibility: a meta-analysis

Y. H. Lee and Song, G. G., Vascular endothelial growth factor gene polymorphisms and psoriasis susceptibility: a meta-analysis, vol. 14, pp. 14396-14405, 2015.

The aim of this study was to explore whether vascular endothelial growth factor (VEGF) polymorphisms confer susceptibil­ity to psoriasis. Meta-analyses were conducted to examine the asso­ciations between the +405 C/G, -460 C/T, -1154 A/G, and -2578 A/C polymorphisms of VEGF and psoriasis using allele contrast and reces­sive, dominant, and additive models. Seven studies on VEGF polymor­phisms and psoriasis involving 1956 subjects (psoriasis patients 665, controls 1291) were included in this meta-analysis.

Association of the IGF-1 rs35767 and rs972936 polymorphisms with the risk of osteoporosis in a Chinese postmenopausal female population

Y. K. Wei, Ma, H. L., Guo, Y. Z., Yang, B. H., and Pang, W. X., Association of the IGF-1 rs35767 and rs972936 polymorphisms with the risk of osteoporosis in a Chinese postmenopausal female population, vol. 14, pp. 14325-14330, 2015.

The aim of our study was to conduct a case-control study in a Chinese postmenopausal population to evaluate the roles of the IGF-1 rs35767 and rs972936 polymorphisms on bone mineral density (BMD) levels and osteoporosis risk. A total of 272 consecutive postmenopausal women with a primary diagnosis of osteoporosis and 272 controls were enrolled in the study between 2012 and 2014. The polymerase chain reaction-restriction fragment length polymorphism method was used to genotype the rs35767 and rs972936 IGF-1 polymorphisms.

Angiotensin II type 1 receptor gene A1166C polymorphism and breast cancer susceptibility

L. Li, Wang, F., Lv, P. W., Zhu, M. Z., He, J. J., Guo, G. C., Gu, Y. T., and Han, M. L., Angiotensin II type 1 receptor gene A1166C polymorphism and breast cancer susceptibility, vol. 14, pp. 15016-15023, 2015.

Numerous studies have evaluated the association between the angiotensin II type-1 receptor (AGTR1) gene A1166C polymorphism and breast cancer risk. However, the specific association is controversial. The aim of the present study was to derive a more precise estimation of the relationship. A comprehensive research was conducted of the PubMed and the Google Scholar databases through February 2015. Data were assessed using STATA version 12.0. Pooled odds ratios with 95%CIs were derived from the fixed-effect or random-effect models.

Meta-analysis of the relationship between XRCC3 T241M polymorphism and colorectal cancer susceptibility

L. Z. Zhang, Li, Y. S., and Liu, H. Z., Meta-analysis of the relationship between XRCC3 T241M polymorphism and colorectal cancer susceptibility, vol. 14, pp. 14831-14839, 2015.

Numerous studies have evaluated the relationship between the T241M polymorphism of the X-ray repair cross-complementing group 3 (XRCC3) gene and colorectal cancer (CRC) risk. However, the specific relationship remains controversial. We conducted meta-analysis to investigate the relationship between the XRCC3 T241M polymorphism and CRC risk. The PubMed and Embase databases were searched for relevant studies investigating the relationship between the XRCC3 T241M polymorphism and CRC risk.

Association between alcohol dehydrogenase 1C gene *1/*2 polymorphism and pancreatitis risk: a meta-analysis

F. Fang, Pan, J., Su, G. H., Xu, L. X., Li, G., Li, Z. H., Zhao, H., and Wang, J., Association between alcohol dehydrogenase 1C gene *1/*2 polymorphism and pancreatitis risk: a meta-analysis, vol. 14, pp. 15267-15275, 2015.

Numerous studies have focused on the relationship be­tween alcohol dehydrogenase 1C gene (ADH1C) *1/*2 polymorphism (Ile350Val, rs698, also known as ADH1C *1/*2) and pancreatitis risk, but the results have been inconsistent. Thus, we conducted a meta-anal­ysis to more precisely estimate this association. Relevant publications were searched in several widely used databases and 9 eligible studies were included in the meta-analysis. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association.

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