Polymorphism

APOA5 -1131T/C polymorphism and coronary artery disease susceptibility in Chinese population: an updated meta-analysis

J. Zhang, Wan, D. G., Song, H. L., and Zhang, W. G., APOA5 -1131T/C polymorphism and coronary artery disease susceptibility in Chinese population: an updated meta-analysis, vol. 14. pp. 12330-12339, 2015.

Although many studies have investigated the association of the APOA5 -1131T/C polymorphism with coronary artery disease (CAD), definite conclusions have not been drawn. To understand the effects of the APOA5 -1131T/C polymorphism on the risk of developing CAD, we performed an updated meta-analysis in the Chinese population. Relevant studies published till April 2015 were identified from databases such as PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure, and Chinese Biology Medicine.

CCDC26 rs4295627 polymorphism (8q24.21) and glioma risk: a meta-analysis

H. W. Lu, Huang, M., Wang, J. H., Sun, X. L., and Ke, Y. Q., CCDC26 rs4295627 polymorphism (8q24.21) and glioma risk: a meta-analysis, vol. 14, pp. 12074-12084, 2015.

The association between the CCDC26 rs4295627 single nucleotide polymorphism (SNP) and the glioma risk has been studied previously, but these studies have yielded conflicting results. The aim of the present study is to analyze this association more vigorously, by means of a meta-analysis. A comprehensive literature search was performed in databases PubMed and EMBASE. Six articles including 12 case-control studies in English with 11,368 controls and 5891 cases were eligible for the meta-analysis.

Effect of IL-1β, IL-8, and IL-10 polymorphisms on the development of myocardial infarction

S. Wang, Dai, Y. X., Chen, L. L., Jiang, T., Zheng, M. Q., Li, C. G., Chen, Y. P., Lin, W. H., Zhang, J. F., and Jiang, J., Effect of IL-1β, IL-8, and IL-10 polymorphisms on the development of myocardial infarction, vol. 14, pp. 12016-12021, 2015.

Myocardial infarction (MI) is currently a leading cause of death worldwide, and is caused by various environmental and genetic factors. We therefore conducted a case-control study to investigate the association between polymorphisms in interleukins IL-1β, IL-8, and IL-10 and MI risk. This study recruited 260 MI patients and 285 control subjects. Genotyping of IL-1β +3954C/T, IL-8 -251T/A, IL-10 -1082A/G, and IL-10 -819C/T were assessed using the polymerase chain reaction-restriction fragment length polymorphism method.

Genomic selection for slaughter age in pigs using the Cox frailty model

V. S. Santos, S. Filho, M., Resende, M. D. V., Azevedo, C. F., Lopes, P. S., Guimarães, S. E. F., Glória, L. S., and Silva, F. F., Genomic selection for slaughter age in pigs using the Cox frailty model, vol. 14, pp. 12616-12627, 2015.

The aim of this study was to compare genomic selection methodologies using a linear mixed model and the Cox survival model. We used data from an F2 population of pigs, in which the response variable was the time in days from birth to the culling of the animal and the covariates were 238 markers [237 single nucleotide polymorphism (SNP) plus the halothane gene]. The data were corrected for fixed effects, and the accuracy of the method was determined based on the correlation of the ranks of predicted genomic breeding values (GBVs) in both models with the corrected phenotypic values.

Association of interleukin gene polymorphisms with the risk of coronary artery disease

H. T. Yang, Wang, S. L., Yan, L. J., Qian, P., and Duan, H. Y., Association of interleukin gene polymorphisms with the risk of coronary artery disease, vol. 14, pp. 12489-12496, 2015.

We conducted a case-control study to investigate the genetic variants Interleukin-1β(IL-1β) +3953 C/T (rs1143634), IL-6 -174G/C (rs1800795), IL-8 -251T/A (rs4073), and IL-10 -1082A/G (rs1800896) and -819C/T (rs1800871) in the development of coronary artery disease (CAD). A total of 410 individuals with CAD were enrolled between January 2012 and December 2014.

Association of A-20C polymorphism in the angiotensinogen gene with essential hypertension: a meta-analysis

R. Zeng, Wang, Q. P., Fang, M. X., Zhuang, J., and Fan, R. X., Association of A-20C polymorphism in the angiotensinogen gene with essential hypertension: a meta-analysis, vol. 14, pp. 12984-12992, 2015.

The A-20C polymorphism in the angiotensinogen (AGT) gene has been associated with increased risk of essential hypertension in several studies; however, these studies gave inconsistent results. In this study, we performed a meta-analysis to assess the association between AGT A-20C polymorphism and essential hypertension. Published literature was retrieved from PubMed. Pooled odd’s ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effect models.

Genetic polymorphisms and retinal vein occlusion in an Italian population

L. De Polo, Maltese, P. E., Rigoni, E., Bertelli, M., Cecchin, S., Staurenghi, G., and Stoppa, G., Genetic polymorphisms and retinal vein occlusion in an Italian population, vol. 14, pp. 13337-13341, 2015.

In this study, we assessed the prevalence of polymorphisms in genes involved in hyperhomocysteinemia or hemostasis to shed light on their role, if any, in retinal vein occlusion (RVO). We recruited 37 Italian patients (17 men and 20 women) with a diagnosis of central or branch RVO based on fundus examination and retinal fluorescein angiography, as well as 45 healthy controls. Risk factors and family history of RVO of all subjects were recorded. The distributions of polymorphisms in patients and controls were evaluated using the χ2 test and OR.

Role of proteinase-activated receptor-1 gene polymorphisms in susceptibility to chronic obstructive pulmonary disease

C. M. Yun and Sang, X. Y., Role of proteinase-activated receptor-1 gene polymorphisms in susceptibility to chronic obstructive pulmonary disease, vol. 14, pp. 13215-13220, 2015.

We conducted a case-control study to investigate the association between PAR1 gene polymorphisms and the development of chronic obstructive pulmonary disease (COPD). A total of 270 patients with COPD and 270 control subjects were consecutively recruited between March 2012 and March 2014. A polymerase chain reaction restriction fragment length polymorphism assay was used to assess the polymorphisms PAR1 IVS-14 A/T rs168753 and -506 I/D rs11267092.

Significant interaction of APOE rs4420638 polymorphism with HDL-C and APOA-I levels in coronary heart disease in Han Chinese men

Y. Huang, Ye, H. D., Gao, X., Nie, S., Hong, Q. X., Ji, H. H., Sun, J., Zhou, S. J., Fei, B., Li, K. Q., Zhao, J. K., Wang, Z. P., Xu, M. Q., and Duan, S. W., Significant interaction of APOE rs4420638 polymorphism with HDL-C and APOA-I levels in coronary heart disease in Han Chinese men, vol. 14, pp. 13414-13424, 2015.

Apolipoprotein E (APOE) is recognized for its importance in lipoprotein metabolism and cardiovascular disease. We evaluated the association between APOE rs4420638 genotypes and circulating lipid concentrations along with the risk of coronary heart disease (CHD). We conducted a case-control study involving 1508 individuals to investigate the contribution of rs4420638 to the risk of CHD in Han Chinese. In addition, we performed a meta-analysis to evaluate the association between rs4420638 and CHD in Europeans and Asians.

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