Polymorphism

Genetic variability of ERCC1 and ERCC2 genes involved in the nucleotide excision repair pathway influences the treatment outcome of gastric cancer

D. L. Zheng, Tang, G. D., Chen, Y. N., Zhang, T., Qin, M. B., Zheng, D. L., Tang, G. D., Chen, Y. N., Zhang, T., Qin, M. B., Zheng, D. L., Tang, G. D., Chen, Y. N., Zhang, T., and Qin, M. B., Genetic variability of ERCC1 and ERCC2 genes involved in the nucleotide excision repair pathway influences the treatment outcome of gastric cancer, vol. 15, p. -, 2016.

We conducted a prospective study to investigate whether ERCC1 rs11615 and rs3212986 and ERCC2 rs13181 and rs1799793 gene polymorphisms could serve as potential biomarkers for the prognosis of gastric cancer. Between January 2010 and December 2012, 246 patients with pathologically proven gastric cancer who were receiving platinum-based chemotherapy were recruited from the First Affiliated Hospital of Guangxi Medical University.

CYP1A2-163C/A (rs762551) polymorphism and bladder cancer risk: a case-control study

Y. L. Song, Wang, L., Ren, J. C., Xu, Z. H., Song, Y. L., Wang, L., Ren, J. C., Xu, Z. H., Song, Y. L., Wang, L., Ren, J. C., and Xu, Z. H., CYP1A2-163C/A (rs762551) polymorphism and bladder cancer risk: a case-control study, vol. 15, p. -, 2016.

To date, no study has investigated the association between CYP1A2-163C/A polymorphism and bladder cancer risk in a Chinese population. Here, we extracted genomic DNA from peripheral white blood cells, and differentiated CYP1A2 alleles by polymerase chain reaction-based restriction fragment length polymorphism methods. Differences in genotype frequencies between the cases and controls were evaluated using a chi-square test. The odds ratio (OR) and its 95% confidence interval (CI) were calculated using an unconditional logistic regression model.

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