Polymorphism

Role of IL-10 gene polymorphisms in the development of acute pancreatitis

B. Z. Jiang, Tang, L., Xue, H., Liu, D. P., Jiang, B. Z., Tang, L., Xue, H., and Liu, D. P., Role of IL-10 gene polymorphisms in the development of acute pancreatitis, vol. 15, p. -, 2016.

Recent studies have suggested that chemokines contribute to the initiation and development of acute pancreatitis. We evaluated the relationship between IL-10 gene polymorphisms (-1082A/G and -819T/C) and development of acute pancreatitis in the Chinese population, in order to provide data for screening high-risk Chinese individuals. In total, 182 patients with confirmed cases of acute pancreatitis and 262 control subjects were recruited from the Shaanxi Provincial People’s Hospital between April 2012 and December 2014.

Identification of trends in scientific publications related to genetic polymorphisms in gestational diabetes mellitus

J. S. Gomes, Minasi, L. B., da Cruz, A. D., Rodrigues, F. M., Gomes, J. S., Minasi, L. B., da Cruz, A. D., and Rodrigues, F. M., Identification of trends in scientific publications related to genetic polymorphisms in gestational diabetes mellitus, vol. 15, p. -, 2016.

Gestational diabetes is a genetic multifactorial systemic disease that has been extensively studied. Consequently, there is a large volume of scientific literature pertaining to genes associated with gestational diabetes. The aim of this study was to characterize the main trends in scientific publications focusing on the associations between genetic polymorphisms and gestational diabetes mellitus (GDM).

Association between interleukin-10 gene polymorphisms and susceptibility to diabetic nephropathy in a Chinese population

D. H. Ma, Xu, Q. Y., Liu, Y., Zhai, Q. Q., Guo, M. H., Ma, D. H., Xu, Q. Y., Liu, Y., Zhai, Q. Q., and Guo, M. H., Association between interleukin-10 gene polymorphisms and susceptibility to diabetic nephropathy in a Chinese population, vol. 15, p. -, 2016.

In this study, we investigated the association between the interleukin (IL)-10 -592C/A, -819C/T, and -1082G/A genetic variations and susceptibility to diabetic nephropathy in a Chinese population. The IL-10 -592C/A, -819C/T, and -1082G/A polymorphisms were genotyped in diabetic nephropathy patient and control samples by polymerase chain reaction-restriction fragment length polymorphism. The results were then statistically analyzed using SPSS 17.0.

Investigating the role of polymorphisms in miR-146a, -149, and -196a2 in the development of gastric cancer

J. Y. Gu, Tu, L., Gu, J. Y., and Tu, L., Investigating the role of polymorphisms in miR-146a, -149, and -196a2 in the development of gastric cancer, vol. 15, p. -, 2016.

Here, we performed a case-control study to investigate the role of miR-146a, miR-149, and miR-196a2 polymorphisms in the development of gastric cancer using a hospital-based case-control design. A total of 186 gastric cancer patients and 186 control subjects were enrolled from Ren Ji Hospital between January 2012 and October 2014. MicroRNAs miR-146a, miR-149, and miR-196a2 were genotyped by polymerase chain reaction coupled with restriction fragment length polymorphism.

Association between matrix metalloproteinase-9 rs3918242 polymorphism and development of coronary artery disease in a Chinese population

L. M. Qin, Qin, G. M., Shi, X. H., Wang, A. L., Zuo, H., Qin, L. M., Qin, G. M., Shi, X. H., Wang, A. L., and Zuo, H., Association between matrix metalloproteinase-9 rs3918242 polymorphism and development of coronary artery disease in a Chinese population, vol. 15, p. -, 2016.

We conducted a case-control study to investigate the role of one single nucleotide polymorphism of MMP-9 rs3918242 in the development of coronary artery disease. The rs3918242 was amplified with 435-bp DNA fragments using polymerase chain reaction coupled with restriction fragment length polymorphism.

Association between a microRNA-214 binding site polymorphism in the methylenetetrahydrofolate reductase gene and esophageal squamous cell carcinoma

G. R. Shen, Li, W. Z., Liu, Y. C., Li, X. P., Yuan, H. Y., Shen, G. R., Li, W. Z., Liu, Y. C., Li, X. P., and Yuan, H. Y., Association between a microRNA-214 binding site polymorphism in the methylenetetrahydrofolate reductase gene and esophageal squamous cell carcinoma, vol. 15, p. -, 2016.

MicroRNAs (miRNAs) are key regulators of gene expression and play an important role in the development and progression of various diseases including esophageal squamous cell carcinoma (ESCC). In this study, we determined whether a polymorphism at the miR-214 binding site in the 3'-untranslated region (3'-UTR) of the methylenetetrahydrofolate reductase gene (MTHFR) is associated with susceptibility to ESCC. A total of 448 ESCC cases and 460 gender- and age-matched subjects were recruited for the study.

Role and diagnostic value of gene variants in assessing the risk of chronic obstructive pulmonary disease

Z. P. Yan, Tong, X., Liu, S. T., Ma, Y., Peng, S. F., Yang, X., Fan, H., Yan, Z. P., Tong, X., Liu, S. T., Ma, Y., Peng, S. F., Yang, X., and Fan, H., Role and diagnostic value of gene variants in assessing the risk of chronic obstructive pulmonary disease, vol. 15, p. -, 2016.

Meta-analyses have revealed many positive associations between gene variants and susceptibility to chronic obstructive pulmonary disease (COPD). However, some of those positive results may be false positives. Therefore, we investigated the genetic polymorphisms associated with COPD risk and determined their diagnostic value.

CYP2C19 polymorphisms in acute coronary syndrome patients undergoing clopidogrel therapy in Zhengzhou population

Y. M. Guo, Zhao, Z. C., Zhang, L., Li, H. Z., Li, Z., Sun, H. L., Guo, Y. M., Zhao, Z. C., Zhang, L., Li, H. Z., Li, Z., and Sun, H. L., CYP2C19 polymorphisms in acute coronary syndrome patients undergoing clopidogrel therapy in Zhengzhou population, vol. 15, p. -, 2016.

The goal of this study was to explore the polymorphisms of CYP2C19 (CYP2C19*2, CYP2C19*3) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) on clopidogrel therapy in Zhengzhou city for guidance on clinical medication and reduction in the incidence of thromboembolic events. Two hundred and thirty-four ACS patients undergoing PCI were included in the study, including 171 males (average age = 64.13 ± 12 years) and 63 females (average age = 67.86 ± 10.20 years).

ERCC1 C118T polymorphism has predictive value for platinum-based chemotherapy in patients with late-stage bladder cancer

Z. C. Xu, Cai, H. Z., Li, X., Xu, W. Z., Xu, T., Yu, B., Zou, Q., Xu, L., Xu, Z. C., Cai, H. Z., Li, X., Xu, W. Z., Xu, T., Yu, B., Zou, Q., and Xu, L., ERCC1 C118T polymorphism has predictive value for platinum-based chemotherapy in patients with late-stage bladder cancer, vol. 15, p. -, 2016.

This study aims to investigate the association between ERCC1 codon C118T polymorphism and the response rate of platinum-based chemotherapy in patients with late-stage bladder cancer. A total of 41 eligible patients histologically confirmed as having stage IV muscle-invasive transitional cell carcinoma of the bladder were treated with platinum-based chemotherapy for 2-6 cycles. The genotypes of patients were determined by PCR amplification of genomic DNA followed by restriction enzyme digestion. Positive responses were categorized as complete and partial responses.

Association of CYP1A1 MspI polymorphism with oral cancer risk in Asian populations: a meta-analysis

J. L. Xu, Xia, R., Sun, L., Min, X., Sun, Z. H., Liu, C., Zhang, H., Zhu, Y. M., Xu, J. L., Xia, R., Sun, L., Min, X., Sun, Z. H., Liu, C., Zhang, H., and Zhu, Y. M., Association of CYP1A1 MspI polymorphism with oral cancer risk in Asian populations: a meta-analysis, vol. 15, p. -, 2016.

Numerous studies regarding the association between the CYP1A1 MspI polymorphism and oral cancer risk in Asian populations have shown controversial results. To get a more precise estimation of this relationship, we conducted a comprehensive meta-analysis. PubMed, the Cochrane Library, Elsevier Science Direct, Web of Knowledge, the Chinese National Knowledge Infrastructure, VIP, and Wan Fang Med Online were searched. Pooled odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated using fixed-effects or random-effects models.

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