Polymorphism -1562C/T

Matrix metalloproteinase 9 -1562C/T polymorphism increased protein levels in patients with colorectal cancer in a sample from southeastern Brazil

C. R. Hoelzle, Magalhães, K. C. S. F., Carvalho, S. S., Santos, G. A., Maia, I. M., Sousa, M. C. P. S., Andrade-Filho, J. S., Cruz, G. M. G., Simões, R. T., Hoelzle, C. R., Magalhães, K. C. S. F., Carvalho, S. S., Santos, G. A., Maia, I. M., Sousa, M. C. P. S., Andrade-Filho, J. S., Cruz, G. M. G., Simões, R. T., Hoelzle, C. R., Magalhães, K. C. S. F., Carvalho, S. S., Santos, G. A., Maia, I. M., Sousa, M. C. P. S., Andrade-Filho, J. S., Cruz, G. M. G., and Simões, R. T., Matrix metalloproteinase 9 -1562C/T polymorphism increased protein levels in patients with colorectal cancer in a sample from southeastern Brazil, vol. 15, p. -, 2016.

We examined whether the allelic and/or genotypic profile of locus -1562C/T of the matrix metalloproteinase (MMP-9) gene influences the protein expression levels of MMP-9 in patients with colorectal cancer (CRC) compared with controls. A total of 104 patients with CRC and 84 controls were evaluated. Peripheral blood was collected from both groups and DNA extraction was performed for -1562C/T genotyping; the plasma was used for MMP-9 quantification. The CT genotype was associated with increased MMP-9 expression (P = 0.0211).

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