Polymorphism

Genetic variability of XRCC1 influences the treatment outcome of gastric cancer

H. Q. Hu, Wang, F., Du, X., Zhao, X. Z., Jin, Z., Hou, M. X., Hu, H. Q., Wang, F., Du, X., Zhao, X. Z., Jin, Z., and Hou, M. X., Genetic variability of XRCC1 influences the treatment outcome of gastric cancer, vol. 15, p. -, 2016.

We aimed to investigate the role of XRCC1 codon 194 (Arg>Trp), 280 (Arg>His), and 399 (Arg>Gln) polymorphisms in response to chemotherapy and the overall survival of gastric cancer patients. A total of 172 patients were recruited for our study between January 2010 and March 2012. Genotyping of the three XRCC1 codons was carried out by restriction fragment length polymorphism polymerase chain reaction.

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