Vulnerability of atherosclerotic plaques is associated with type I interferon in a murine model of lupus and atherosclerosis
“Vulnerability of atherosclerotic plaques is associated with type I interferon in a murine model of lupus and atherosclerosis”, vol. 14, pp. 14871-14881, 2015.
, This study aimed to investigate the relationship between type I interferon (IFN-I) and plaque stability in pristane-treated apolipoprotein E-knockout (ApoE-/-) mice. Antinuclear antibody (ANA) and extractable nuclear antigen antibody (ENA) levels were measured by immunofluorescence and enzyme-linked immunospot assay. Atherosclerotic plaques were detected by Sirius red/fast green staining. Cell apoptosis was detected by terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick-end labeling. Gene expression was determined by real-time PCR analyses.