Physiological activity

Correlation between liver cancer occurrence and gene expression profiles in rat liver tissue

C. S. Xu, Wang, G. P., Zhang, L. X., Chang, C. F., Zhi, J., and Hao, Y. P., Correlation between liver cancer occurrence and gene expression profiles in rat liver tissue, vol. 10, pp. 3480-3513, 2011.

Liver cancer (LC) is generally characterized by malignant cell proliferation and growth; it normally develops in stages that progress from non-specific injury of the liver to liver fibrosis, liver cirrhosis, dysplasia nodules, and liver carcinoma. We used a rat model of diethylnitrosamine (DENA)-induced LC; a Rat Genome 230 2.0 Array was used to detect gene expression profile of liver tissues from male rats 5, 8, 12, 16, and 18 weeks following the beginning of DENA-induced LC.

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