Hypoxia enhances periodontal ligament stem cell proliferation via the MAPK signaling pathway
“Hypoxia enhances periodontal ligament stem cell proliferation via the MAPK signaling pathway”, vol. 15, no. 4, p. -, 2016.,
The function of SIRT1 in the proliferation and osteoblastic differentiation of dental stem cells is unclear. The aim of this study was to assess the roles of SIRT1 in these processes using periodontal ligament stem cells (PDLSCs) and stem cells from apical papilla (SCAPs). A defined concentration of resveratrol, an SIRT1 activator, or nicotinamide, an SIRT1 inhibitor, was administered to PDLSCs, SCAPs, and a mixed group of the two cell lines, and their effects on these processes analyzed. Cell proliferation was tested using microtitration with a tetrazolium dye (MTT).