Pathway

Construction of a protein-protein interaction network of Wilms’ tumor and pathway prediction of molecular complexes

W. J. Teng, Zhou, C., Liu, L. J., Cao, X. J., Zhuang, J., Liu, G. X., Sun, C. G., Teng, W. J., Zhou, C., Liu, L. J., Cao, X. J., Zhuang, J., Liu, G. X., and Sun, C. G., Construction of a protein-protein interaction network of Wilms’ tumor and pathway prediction of molecular complexes, vol. 15, p. -, 2016.

Wilms’ tumor (WT), or nephroblastoma, is the most common malignant renal cancer that affects the pediatric population. Great progress has been achieved in the treatment of WT, but it cannot be cured at present. Nonetheless, a protein-protein interaction network of WT should provide some new ideas and methods. The purpose of this study was to analyze the protein-protein interaction network of WT.

Identifying significant pathways of hepatitis B virus-related hepatocellular carcinoma based on crosstalk and network pathways

L. M. Wen, Wu, W. Z., Peng, X. C., Wen, L. M., Wu, W. Z., and Peng, X. C., Identifying significant pathways of hepatitis B virus-related hepatocellular carcinoma based on crosstalk and network pathways, vol. 15, p. -, 2016.

This study aims to identify significant pathways in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) based on the pathway network strategy. We proposed a pathway network where a protein-protein interaction (PPI) network was integrated with the crosstalk of pathways. Pathway data were first obtained from background PPI network, Reactome pathway database, and common genes between mRNA differentially expressed genes (DEGs), and miRNA target genes of HBV-related HCC.

Deep RNA sequencing elucidates microRNA-regulated molecular pathways in ischemic cardiomyopathy and nonischemic cardiomyopathy

X. Li, Liu, C. Y., Li, Y. S., Xu, J., Li, D. G., Han, D., Li, X., Liu, C. Y., Li, Y. S., Xu, J., Li, D. G., Han, D., Li, X., Liu, C. Y., Li, Y. S., Xu, J., Li, D. G., and Han, D., Deep RNA sequencing elucidates microRNA-regulated molecular pathways in ischemic cardiomyopathy and nonischemic cardiomyopathy, vol. 15, p. -, 2016.

Deregulation of cardiac miRNA gene-regulatory networks is a feature of different heart diseases, including ischemic (ICM) and nonischemic (NICM) cardiomyopathy. Here, based on the paired miRNA and mRNA expression profiles in ICM and NICM, we identified the differentially expressed miRNAs and mRNAs and the expression signatures distinguishing ICM/NICM from control samples. Furthermore, we constructed a functional miRNA network for each disease.

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