Pathology

Effect of age on the immune system and pathology of mice with chronic graft-versus-host disease lupus nephritis

X. F. Ma, Xu, F. L., Gao, L. F., Wang, Y. X., and Pan, Z. B., Effect of age on the immune system and pathology of mice with chronic graft-versus-host disease lupus nephritis, vol. 14, pp. 10999-11005, 2015.

We investigated the effect of age on the expression of immune molecules [ANA, C4, double stranded DNA (dsDNA), CD16/32, CD19, CD3, and CD64], urine protein, and pathology in mice with chronic graft-versus-host disease (cGVHD) lupus nephritis (LN), and their relationship with reactivity index score. Mouse models of cGVHD LN were established, and mice were randomly divided into four aged-based groups of nine mice each. Serum levels of ANA, C4, and dsDNA were determined, the urine protein levels were assessed, and expression levels of CD16/32, CD19, CD3, and CD64 were measured.

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