Pathogenesis

RUNX3 promoter methylation correlation with pathogenesis of hepatocellular carcinoma in Asians

W. Lu, Liu, Y., Liu, L. - L., Zhuang, P. - H., Lu, W., Liu, Y., Liu, L. - L., and Zhuang, P. - H., “RUNX3 promoter methylation correlation with pathogenesis of hepatocellular carcinoma in Asians”, vol. 15, p. -, 2016.

The aim of this study was to elucidate the role of RUNX3 promoter methylation in the pathogenesis of hepatocellular carcinoma (HCC) among Asians. For this purpose, we performed a comprehensive search of Chinese and English language scientific literature databases using stringent selection criteria; ultimately, we identified relevant studies that specifically assessed the correlation between RUNX3 promoter methylation and HCC. All data was retrieved and analyzed by two independent investigators using the STATA software (version 12.0).

Role of survivin in the pathogenesis of papillary thyroid carcinoma

J. Y. Li, Shi, J., Sang, J. F., Yao, Y. Z., Wang, X. C., and Su, L., “Role of survivin in the pathogenesis of papillary thyroid carcinoma”, vol. 14, pp. 15102-15111, 2015.

The purpose of this study was to assess the correlation between the survivin gene and the occurrence and pathogenesis of papillary thyroid carcinoma (PTC). Sixty patients with PTC and no preoperative chemotherapy were recruited for the study and 30 thyrophyma patients receiving operative treatment in Drum Tower Hospital (Nanjing, China) were included as the control group. The protein expression levels of survivin were assessed by immunoblotting and immunohistochemical analysis of tissues from both patient groups.

Elevated serum homocysteine level in the development of diabetic peripheral neuropathy

L. Q. Zheng, Zhang, H. L., Guan, Z. H., Hu, M. Y., Zhang, T., and Ge, S. J., “Elevated serum homocysteine level in the development of diabetic peripheral neuropathy”, vol. 14, pp. 15365-15375, 2015.

The development of diabetic peripheral neuropathy (DPN) is always followed by changes in vascular endothelial cells that are related to the reactivity of the homocysteine (Hcy) sulfhydryl group. In this meta-analysis, we investigated the association of Hcy with the pathogenesis and progression of DPN. We screened the Embase, Ovid, PubMed, Web of Science, Wangfang, and China National Knowledge Infrastructure databases.

Subscribe to Pathogenesis