Parkinson’s disease

Effect of siRNA-induced silencing of cellular prion protein on tyrosine hydroxylase expression in the substantia nigra of a rat model of Parkinson’s disease

X. Wang, Yang, H. A., Wang, X. N., Du, Y. F., Wang, X., Yang, H. A., Wang, X. N., and Du, Y. F., Effect of siRNA-induced silencing of cellular prion protein on tyrosine hydroxylase expression in the substantia nigra of a rat model of Parkinson’s disease, vol. 15, p. -, 2016.

The most significant pathological feature of Parkinson’s disease (PD) is the progressive degeneration of dopaminergic (DA) neurons in the substantia nigra. Currently, available treatments for PD cannot prevent the loss of DA neurons. Tyrosine hydroxylase (TH) expressed in substantia nigra neurons catalyzes the conversion of tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA), which is the rate-limiting step of DA biosynthesis. Major reasons for PD occurrence include decreased TH activity in the substantia nigra and secondary DA suppression.

Association between monoamine oxidase B A644G polymorphism and Parkinson’s disease risk: a meta-analysis in the Chinese population

J. J. Liu, Wang, W., Meng, M., Liang, C. S., and Zhang, J. W., Association between monoamine oxidase B A644G polymorphism and Parkinson’s disease risk: a meta-analysis in the Chinese population, vol. 15, p. -, 2016.

Although various individual studies have evaluated the correlation between monoamine oxidase B (MAOB), polymorphism, and Parkinson’s disease (PD), the results remain inconclusive. Therefore, we performed a meta-analysis in the Chinese population to provide comprehensive data on the association between the MAOB polymorphism and PD. Eligible studies were identified via databases such as PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure, and Chinese Biology Medicine, throughout November 2015.

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