Pancreatic cancer

Association of XRCC1 gene polymorphisms and pancreatic cancer risk in a Chinese population

L. J. Wang, Wang, H. T., Wang, X. X., Wang, L. J., Wang, H. T., and Wang, X. X., Association of XRCC1 gene polymorphisms and pancreatic cancer risk in a Chinese population, vol. 15, p. -, 2016.

We conducted a case-control study to assess the role of the XRCC1 Arg399Gln, Arg280His, and Arg194Trp gene polymorphisms in pancreatic cancer susceptibility in a Chinese population. A total of 152 patients diagnosed with pancreatic cancer and 264 control subjects were enrolled in this study between March 2012 and October 2014. XRCC1 Arg399Gln, Arg280His, and Arg194Trp were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method.

Mitochondrial tRNALeu(CUN) A12307G variant may not be associated pancreatic cancer

Y. Li, Huang, A. W., Chen, Y. Z., Yang, W. J., Zhou, M. T., Sun, H. W., Li, Y., Huang, A. W., Chen, Y. Z., Yang, W. J., Zhou, M. T., and Sun, H. W., Mitochondrial tRNALeu(CUN) A12307G variant may not be associated pancreatic cancer, vol. 15, p. -, 2016.

Mitochondrial DNA mutations that lead to mitochondrial dysfunction have long been proposed to play important roles in the development of pancreatic cancer. Of these, alterations to mitochondrial tRNA genes constitute the largest group. Most recently, a variation at position 12307 in the gene encoding tRNALeu(CUN) has been reported to be associated with this disease. However, the molecular mechanism underlying this relationship remains poorly understood.

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