Pancreatic cancer

Mitochondrial tRNALeu(CUN) A12307G variant may not be associated pancreatic cancer

Y. Li, Huang, A. W., Chen, Y. Z., Yang, W. J., Zhou, M. T., Sun, H. W., Li, Y., Huang, A. W., Chen, Y. Z., Yang, W. J., Zhou, M. T., and Sun, H. W., Mitochondrial tRNALeu(CUN) A12307G variant may not be associated pancreatic cancer, vol. 15, p. -, 2016.

Mitochondrial DNA mutations that lead to mitochondrial dysfunction have long been proposed to play important roles in the development of pancreatic cancer. Of these, alterations to mitochondrial tRNA genes constitute the largest group. Most recently, a variation at position 12307 in the gene encoding tRNALeu(CUN) has been reported to be associated with this disease. However, the molecular mechanism underlying this relationship remains poorly understood.

Role of single nucleotide polymorphisms of DNA repair genes in susceptibility to pancreatic cancer in Chinese population

M. F. Ying, Zhao, R., Ying, M. F., Zhao, R., Ying, M. F., and Zhao, R., Role of single nucleotide polymorphisms of DNA repair genes in susceptibility to pancreatic cancer in Chinese population, vol. 15, p. -, 2016.

We conducted a case-control study to investigate the role of ERCC1-ERCC5 gene polymorphisms in the risk of pancreatic cancer. This study included 195 patients who were newly diagnosed with histopathologically confirmed primary pancreatic cancer, and 254 controls were recruited from Sir Run Run Shaw Hospital, between January 2012 and December 2014. Genotyping of ERCC1 rs3212986 and rs11615, ERCC2 rs13181, ERCC3 rs4150441, ERCC4 rs6498486, and ERCC5 rs2094258 polymorphisms was carried out using polymerase chain reaction coupled with restriction fragment length polymorphism.

Subscribe to Pancreatic cancer