Pancreatic cancer

Effects of gemcitabine on radiosensitization, apoptosis, and Bcl-2 and Bax protein expression in human pancreatic cancer xenografts in nude mice

Z. T. Shen, Wu, X. H., Wang, L., Li, B., and Zhu, X. X., “Effects of gemcitabine on radiosensitization, apoptosis, and Bcl-2 and Bax protein expression in human pancreatic cancer xenografts in nude mice”, vol. 14, pp. 15587-15596, 2015.

The aim of this study was to evaluate the radiosensitizing effects of gemcitabine towards human pancreatic cancer xenografts. A human pancreatic cancer xenograft model was established in nude mice, 36 of which were randomly divided into 6 treatment groups. Tumors were measured every 2 days, and the tumor volumes, growth delays, and inhibition rates were compared to evaluate the gemcitabine enhancement factor.

MicroRNA-215 functions as a tumor suppressor and directly targets ZEB2 in human pancreatic cancer

Q. W. Li, Zhou, T., Wang, F., Jiang, M., Liu, C. B., Zhang, K. R., Zhou, Q., Tian, Z., and Hu, K. W., “MicroRNA-215 functions as a tumor suppressor and directly targets ZEB2 in human pancreatic cancer”, vol. 14, pp. 16133-16145, 2015.

It has been shown that microRNA-215 (miR-215) is dysregulated in several human malignancies, and this correlates with tumor progression. However, its expression and function in pancreatic cancer is still unclear. The aim of this study was to explore the effects of miR-215 on pancreatic cancer formation and progression. Using quantitative RT-PCR, we detected miR-215 expression in pancreatic cancer cell lines and primary tumor tissues. The association of miR-215 expression with clinicopathological factors and prognosis was also analyzed.

Reduced miRNA-218 expression in pancreatic cancer patients as a predictor of poor prognosis

B. - S. Li, Liu, H., and Yang, W. - L., “Reduced miRNA-218 expression in pancreatic cancer patients as a predictor of poor prognosis”, vol. 14, pp. 16372-16378, 2015.

microRNA-218 (miR-218) is a vertebrate-specific miRNA that plays a crucial role in tumorigenesis and tumor progression. This study analyzed the miR-218 expression level and clinical significance in pancreatic cancer. One hundred and seven pairs of pancreatic cancer and adjacent normal tissues were analyzed by quantitative reverse-transcriptase polymerase chain reaction. The correlation between miR-218 expression and clinicopathological characters was determined by the two-sample Student t-test.

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