Propofol suppresses proliferation and invasion of pancreatic cancer cells by upregulating microRNA-133a expression
“Propofol suppresses proliferation and invasion of pancreatic cancer cells by upregulating microRNA-133a expression”, vol. 14, pp. 7529-7537, 2015.
, Propofol is a commonly used intravenous anesthetic. We evaluated its effects on the behavior of human pancreatic cancer cells and the underlying molecular mechanisms. The effects of propofol on Panc-1 cell proliferation, apoptosis, and invasion were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, caspase-3 activity measurement, and Matrigel invasion assay. Quantitative polymerase chain reaction (qPCR) was used to assess microRNA-133a (miR-133a) expression.