Pancreatic cancer

Propofol suppresses proliferation and invasion of pancreatic cancer cells by upregulating microRNA-133a expression

Z. T. Wang, Gong, H. Y., Zheng, F., Liu, D. J., and Dong, T. L., Propofol suppresses proliferation and invasion of pancreatic cancer cells by upregulating microRNA-133a expression, vol. 14, pp. 7529-7537, 2015.

Propofol is a commonly used intravenous anesthetic. We evaluated its effects on the behavior of human pancreatic cancer cells and the underlying molecular mechanisms. The effects of propofol on Panc-1 cell proliferation, apoptosis, and invasion were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, caspase-3 activity measurement, and Matrigel invasion assay. Quantitative polymerase chain reaction (qPCR) was used to assess microRNA-133a (miR-133a) expression.

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