p53 codon 72 polymorphism

Meta-analysis demonstrates association between Arg72Pro polymorphism in the P53 gene and susceptibility to keloids in the Chinese population

Y. Wu, Wang, B., Li, Y. H., Xu, X. G., Luo, Y. J., Chen, J. Z. S., Wei, H. C., Gao, X. H., and Chen, H. D., Meta-analysis demonstrates association between Arg72Pro polymorphism in the P53 gene and susceptibility to keloids in the Chinese population, vol. 11, pp. 1701-1711, 2012.

Although there is evidence suggesting genetic susceptibility for keloids, studies investigating the association between Arg72Pro polymorphism in the P53 gene and tendency to form keloids have given variable results. We made a meta-analysis of the effects of P53 Arg72Pro polymorphism on keloid risk in the Chinese population by conducting searches of the published literature in Pubmed, Embase, CBMdisc, and CNKI databases up to June 2011. Six studies were included in the meta-analysis, with a total of 359 keloid cases and 493 healthy controls.

Primary open angle glaucoma was not found to be associated with p53 codon 72 polymorphism in a Brazilian cohort

R. E. Silva, Arruda, J. T., Rodrigues, F. W., and Moura, K. K. V. O., Primary open angle glaucoma was not found to be associated with p53 codon 72 polymorphism in a Brazilian cohort, vol. 8, pp. 268-272, 2009.

Primary open angle glaucoma (POAG) is the most common type of glaucoma. The p53 codon 72 Arg-Pro (CGC to CCC) polymorphism of exon 4 affects various biological properties; recently, it was reported that this polymorphism affects the ability to induce apoptosis in vitro. Various genotypes have been found to be significantly associated with POAG. We examined the distribution of this polymorphism in 104 unrelated POAG patients and in 58 normal healthy individuals without history of POAG at the Pronto Clínica de Olhos in Goiânia, Brazil.

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