p53

Genetic polymorphisms in patients with endometriosis: an analytical study in Goiânia (Central West of Brazil)

K. S. F. Silva, Moura, K. K. V. O., Silva, K. S. F., and Moura, K. K. V. O., Genetic polymorphisms in patients with endometriosis: an analytical study in Goiânia (Central West of Brazil), vol. 15, p. -, 2016.

In healthy women, intra- and extracellular controls prevent the attachment and proliferation of ectopic endometrial cells. During endometriosis, abnormalities in these control mechanisms permit the survival of endometrial cells, their subsequent attachment to the peritoneal cavity, and disease progression. These abnormal cells cause invasion of tissues and induce an inflammatory response. Several genetic, immunological, and environmental factors contribute to this complex process.

Borax-induced apoptosis in HepG2 cells involves p53, Bcl-2, and Bax

Y. Wei, Yuan, F. J., Zhou, W. B., Wu, L., Chen, L., Wang, J. J., Zhang, Y. S., Wei, Y., Yuan, F. J., Zhou, W. B., Wu, L., Chen, L., Wang, J. J., and Zhang, Y. S., Borax-induced apoptosis in HepG2 cells involves p53, Bcl-2, and Bax, vol. 15, p. -, 2016.

Borax, a boron compound and a salt of boric acid, is known to inhibit the growth of tumor cells. HepG2 cells have been shown to be clearly susceptible to the anti-proliferative effects of borax. However, the specific mechanisms regulating this effect are poorly understood. This study aimed to investigate the pathways underlying the growth inhibition induced by borax in HepG2 cells. The effects of borax on HepG2 cell viability were characterized using MTT. Apoptosis was also verified by annexin V/propidium iodide staining.

Significance of Ebp1 and p53 protein expression in cervical cancer

L. Liu, Li, X. D., Chen, H. Y., Cui, J. S., and Xu, D. Y., Significance of Ebp1 and p53 protein expression in cervical cancer, vol. 14, pp. 11860-11866, 2015.

In this study, the ErbB3-binding protein (Ebp1) and p53 protein expression in cervical cancer tissues, and its significance in the prognosis of the disease was investigated. Ebp1 and p53 protein expression was detected by immunohistochemical analysis in cervical cancer tissues (N = 60) and normal tissues adjacent to the cancer tissues (N = 60). The rates of positive Ebp1 and p53 protein expression were 35.0 and 60.0%, respectively. Ebp1 and p53 were overexpressed in cervical cancer tissues, compared to normal tissues (P < 0.05).

Propofol induces apoptosis and inhibits the proliferation of rat embryonic neural stem cells via gamma-aminobutyric acid type A receptor

J. W. Wang, Cheng, W. W., Xu, T., and Yang, Z. Y., Propofol induces apoptosis and inhibits the proliferation of rat embryonic neural stem cells via gamma-aminobutyric acid type A receptor, vol. 14, pp. 14920-14928, 2015.

We investigated the effect of propofol on the proliferation and viability of rat embryonic neural stem cells (rENSCs) and the potential mechanisms involved. rENSCs were isolated and cultured in vitro and treated with 1, 10, or 50 μM propofol, while the control group was treated with 0.1 μM dimethyl sulfoxide. The effect of propofol on the proliferation and viability of rENSCs was examined by proliferation and apoptosis assays. Real-time polymerase chain reaction was employed to analyze the mRNA expression of checkpoint kinase 1 (Chk1) and p53 in rENSCs exposed to propofol.

Dihydromyricetin induces cell apoptosis via a p53-related pathway in AGS human gastric cancer cells

F. J. Ji, Tian, X. F., Liu, X. W., Fu, L. B., Wu, Y. Y., Fang, X. D., and Jin, H. Y., Dihydromyricetin induces cell apoptosis via a p53-related pathway in AGS human gastric cancer cells, vol. 14, pp. 15564-15571, 2015.

The aim of the present study was to determine the anti­proliferative and pro-apoptotic effects of dihydromyricetin (DHM) on the AGS human gastric cancer cells and their underlying mechanisms. The effects of DHM on AGS cells were evaluated by using 3-(4, 5-di­methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), lactate dehydrogenase, and Annexin V/propidium iodide (PI) double-staining assays. The underlying mechanisms were determined by using quanti­tative real-time polymerase chain reaction.

Polymorphisms of GSTM1, GSTT1, and p53 in Goiânia, Goiás

D. A. Rodrigues, Costa, I. R., Martins, J. V. M., Silva, K. S. Fe, and Moura, K. K. V. O., Polymorphisms of GSTM1, GSTT1, and p53 in Goiânia, Goiás, vol. 14, pp. 17358-17365, 2015.

Genetic polymorphisms are defined as changes within the DNA sequences of genes that have frequencies in the population higher than 1%. The glutathione S-transferases play an important role in the cellular detoxification systems involved in oxidative stress that can lead to accumulation of reactive oxygen species. Epidemiological studies have suggested that individuals with homozygous deletion of glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1) are at higher risk of developing several types of neoplasias.

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