Polymorphism of the OLR1 3'UTR potential microRNA binding site and risk of Alzheimer’s disease: a meta-analysis
“Polymorphism of the OLR1 3'UTR potential microRNA binding site and risk of Alzheimer’s disease: a meta-analysis”, vol. 13, pp. 10162-10172, 2014.,
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that contributes to dementia in the elderly population. Genome-wide linkage analysis has identified chromosome 12p as the AD-susceptible region, which includes lectin-like oxidized low-density lipoprotein receptor 1 (OLR1). The OLR1 +1073 C/T single-nucleotide polymorphism is located in the 3'-untranslated region of the gene and may influence the binding of regulatory microRNAs (miRNAs) and OLR1 protein homeostasis. A number of studies have reported an association between this variant and AD.