Oxidative stress

Effect of uric acid on mitochondrial function and oxidative stress in hepatocytes

Y. Yang, Zhou, Y., Cheng, S., Sun, J. L., Yao, H., Ma, L., Yang, Y., Zhou, Y., Cheng, S., Sun, J. L., Yao, H., and Ma, L., “Effect of uric acid on mitochondrial function and oxidative stress in hepatocytes”, vol. 15, p. -, 2016.

Here, we investigated the effect of uric acid (UA) on hepatocyte mitochondria. Hepatocytes cultured in vitro were treated with varying concentrations of UA. The change in apoptotic activity was detected by flow cytometry. The DNA damage index 8-hydroxy-deoxy-guanosine (8-OHdG) and mitochondrial function indices succinate dehydrogenase (SDH), cytochrome C oxidase (CCO), and adenosine triphosphate (ATP) were detected by enzyme assays. Reactive oxygen species (ROS) accumulation was confirmed by a dichloro-dihydro-fluorescein diacetate assay.

Neuroprotective effect of Amaranthus lividus and Amaranthus tricolor and their effects on gene expression of RAGE during oxidative stress in SH-SY5Y cells

W. Amornrit, Santiyanont, R., Amornrit, W., Santiyanont, R., Amornrit, W., and Santiyanont, R., “Neuroprotective effect of Amaranthus lividus and Amaranthus tricolor and their effects on gene expression of RAGE during oxidative stress in SH-SY5Y cells”, vol. 15, p. -, 2016.

Amaranthus plants, or spinach, are used as food sources worldwide. Amaranthus leaves are rich in antioxidant compounds, which act as free radical scavengers. Oxidative stress caused by the aberrant production of reactive oxygen species (ROS) represents an important mechanism for neuronal dysfunction and cell loss in different neurodegenerative disorders. The neuroprotective effects of antioxidant-containing plants have been extensively demonstrated in different models of neurotoxicity.

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