Osteosarcoma

Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation

R. Wang, Zheng, J., Zhang, D. - S., Yang, Y. - H., and Zhao, Z. - F., Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation, vol. 14, pp. 7315-7325, 2015.

Osteosarcoma is one of the most common primary bone tumors in children and young adults. In this study, we investigated the role of musculoaponeurotic fibrosarcoma oncogene homolog K (MAFK) in osteosarcoma cell proliferation in vitro and the possible pathways that contributed to MAFK-related osteosarcoma development. We first reported that MAFK was expressed at low levels in an osteosarcoma cell line. Furthermore, a significant correlation between MAFK and the Wnt signaling pathway was observed in osteosarcoma by using a gene microarray assay.

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