Osteosarcoma

Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation

R. Wang, Zheng, J., Zhang, D. - S., Yang, Y. - H., and Zhao, Z. - F., Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation, vol. 14, pp. 7315-7325, 2015.

Osteosarcoma is one of the most common primary bone tumors in children and young adults. In this study, we investigated the role of musculoaponeurotic fibrosarcoma oncogene homolog K (MAFK) in osteosarcoma cell proliferation in vitro and the possible pathways that contributed to MAFK-related osteosarcoma development. We first reported that MAFK was expressed at low levels in an osteosarcoma cell line. Furthermore, a significant correlation between MAFK and the Wnt signaling pathway was observed in osteosarcoma by using a gene microarray assay.

Association between ERCC1 and ERCC2 gene polymorphisms and chemotherapy response and overall survival in osteosarcoma

Z. H. Cao, Yin, H. P., Jiang, N., and Yu, B., Association between ERCC1 and ERCC2 gene polymorphisms and chemotherapy response and overall survival in osteosarcoma, vol. 14, pp. 10145-10151, 2015.

We aimed to evaluate the influence of four SNPs in ERCC1 and ERCC2 on the response to cisplatin-based treatment and on clinical outcome in patients with osteosarcoma. We identified 186 patients with osteosarcoma diagnosed between April 2009 and April 2011 who were eligible for inclusion in our study. Genotyping of ERCC1 rs11615, rs3212986, and rs2298881; and ERCC2 rs1799793 and rs13181 was conducted by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.

Association between angiogenic growth factor genetic polymorphisms and the risk of osteosarcoma

H. F. Zhang, Yan, J. P., Zhuang, Y. S., and Han, G. Q., Association between angiogenic growth factor genetic polymorphisms and the risk of osteosarcoma, vol. 14, pp. 10524-10529, 2015.

The aim of this study was to assess the role of the VEGF -2578C/A, +936C/T, and -460T/C gene polymorphisms in the development of osteosarcoma. A total of 182 patients with osteosarcoma and 182 age- and gender-matched healthy controls were enrolled into our study during January 2011 and December 2013. Genotype frequencies of the VEGF -2578C/A and -460T/C alleles in controls were found to be within the parameters of Hardy-Weinberg equilibrium, but the genotype frequencies of +936C/T alleles were not.

Genetic variability of genes involved in DNA repair influence treatment outcome in osteosarcoma

M. J. Wang, Zhu, Y., Guo, X. J., and Tian, Z. Z., Genetic variability of genes involved in DNA repair influence treatment outcome in osteosarcoma, vol. 14, pp. 11652-11657, 2015.

We conducted a perspective study to investigate the role of ERCC1 (rs11615), ERCC2 (rs13181 and rs1799793), ERCC4 (rs1800067), and ERCC5 (rs17655) in NER pathway in the prognosis of osteosarcoma patients. In total, 146 osteosarcoma patients were recruited between 2008 and 2013. ERCC1 rs11615, ERCC2 rs13181 and rs1799793, ERCC4 rs1800067, and ERCC5 rs17655 gene polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism assay.

Investigation of ERCC1 and ERCC2 gene polymorphisms and response to chemotherapy and overall survival in osteosarcoma

Q. Zhang, Lv, L. Y., Li, B. J., Zhang, J., and Wei, F., Investigation of ERCC1 and ERCC2 gene polymorphisms and response to chemotherapy and overall survival in osteosarcoma, vol. 14, pp. 11235-11241, 2015.

We assessed the role of single nucleotide polymorphisms (SNPs) in ERCC1 and ERCC2 genes in the clinical outcomes for osteosarcoma patients receiving cisplatin-based treatment. A perspective study was conducted on 260 patients with osteosarcoma during 2010 and 2011. A polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was used to assess the ERCC1 rs11615 and rs3212986, and the ERCC2 rs1799793 and rs13181 gene polymorphisms.

Osteosarcoma arising from osteochondroma of the tibia: case report and cytogenetic findings

E. E. Engel, Nogueira-Barbosa, M. H., Brassesco, M. S., Silva, G. E. B., Valera, E. T., Peria, F. M., Motta, T. C., and Tone, L. G., Osteosarcoma arising from osteochondroma of the tibia: case report and cytogenetic findings, vol. 11. pp. 448-454, 2012.

Osteochondroma is a cartilage capped benign tumor developing mainly at the juxta-epiphyseal region of long bones. The rate of malignant transformation, mainly into chondrosarcoma, is estimated to be less than 1-3%. Transformation into osteosarcoma is very rare and has been reported only thirteen times. There is little information on treatment and outcome. We report the case of a secondary osteosarcoma arising in the left tibia of a 23-year-old male, 10 years after the initial diagnosis of osteochondroma and after two partial resections.

Pages

Subscribe to Osteosarcoma