Osteoarthritis

Differential expression of COX-2 in osteoarthritis and rheumatoid arthritis

H. W. Fan, Liu, G. Y., Zhao, C. F., Li, X. F., and Yang, X. Y., Differential expression of COX-2 in osteoarthritis and rheumatoid arthritis, vol. 14, pp. 12872-12879, 2015.

In this study, we investigated the differential expression profiles of cyclooxygenase-2 (COX-2) mRNA and proteins in osteoarthritis (OA) and rheumatoid arthritis (RA) patients to elucidate the role of COX-2 expression in the pathogenesis and development of these diseases and to provide novel drug targets for treating arthritis. A total of 60 patients who received arthroscopic surgeries for treating OA (N = 30) or RA (N = 30) were examined. Fifteen normal synovial tissue samples were included as the control group.

Effect of high-intensity exercise on interleukin-15 expression in rabbit synovia

Y. H. Wang, Li, X. D., Zhu, W. B., and Sun, G. F., Effect of high-intensity exercise on interleukin-15 expression in rabbit synovia, vol. 14, pp. 13852-13859, 2015.

The objective of this study was to examine the effect of high-intensity exercise on interleukin-15 (IL-15) expression in rabbit synovia. We utilized 24 New Zealand white rabbits, which were randomly divided equally into high-intensity exercise and control groups. The former were forced to run for 60 min/day over 4 weeks at the speed of 30 m/min. The histological changes of cartilage and knee joint synovia were investigated with hematoxylin and eosin staining. Immunohistochemistry and enzyme-linked immunosorbent assays were performed to measure IL-15 expression.

Cartilage oligomeric matrix protein and matrix metalloproteinase-3 expression in the serum and joint fluid of a reversible osteoarthritis rabbit model

X. Q. Chu, Wang, J. J., Dou, L. D., and Zhao, G., Cartilage oligomeric matrix protein and matrix metalloproteinase-3 expression in the serum and joint fluid of a reversible osteoarthritis rabbit model, vol. 14, pp. 14207-14215, 2015.

The main pathological characteristic of osteoarthritis (OA) is cartilage damage. We explored cartilage oligomeric matrix protein (COMP) and matrix metalloproteinase-3 (MMP-3) changes during articular cartilage injury and repair. Rabbits were randomly divided into the following: a blank control group; groups M1, M2, and M3, in which breaking was performed for 2, 4, and 6 weeks, respectively; and groups L1, L2, and L3, in which breaking was discontinued for 2, 4, and 6 weeks, respectively, following a 4-week recovery period. There are 7 rabbits in each group.

Correlation between interleukin-6 expression in articular cartilage bone and osteoarthritis

X. Q. Qu, Wang, W. J., Tang, S. S., Liu, Y., and Wang, J. L., Correlation between interleukin-6 expression in articular cartilage bone and osteoarthritis, vol. 14, pp. 14189-14195, 2015.

This study aimed to investigate the expressional profile of interleukin-6 (IL-6) in articular cartilage bone of osteoarthritis (OA) patients and its correlation with OA. A total of 30 articular cartilage bone samples from knee OA patients, which were collected by knee arthroscopy or articular surgery, comprised the study group, and 30 samples of normal articular cartilage tissue comprised the control group.

Correlation of CD4+ CD25+ Foxp3+ Treg with the recovery of joint function after total knee replacement in rats with osteoarthritis

S. - Y. Guo, Ding, Y. - J., Li, L., Zhang, T., Zhang, Z. - Z., and Zhang, E. - S., Correlation of CD4+ CD25+ Foxp3+ Treg with the recovery of joint function after total knee replacement in rats with osteoarthritis, vol. 14, pp. 7290-7296, 2015.

In this study, we observed changes in CD4+ CD25+ Foxp3+ Treg expression in rats with osteoarthritis (OA) to explore the role that CD4+ CD25+ Foxp3+ Treg plays in the decline in the condition of OA rats. Thirty rats were randomly divided into 2 groups equally and OA was induced in rats in the model group by injection of papain and l-cysteine into the right knee joint.

Upregulation of fibroblast growth factor 1 in the synovial membranes of patients with late stage osteoarthritis

R. Li, Wang, B., He, C. Q., Yang, Y. Q., Guo, H., Chen, Y., and Du, T. H., Upregulation of fibroblast growth factor 1 in the synovial membranes of patients with late stage osteoarthritis, vol. 14, pp. 11191-11199, 2015.

Osteoarthritis (OA) is a degenerative disease of the systemic joint that involves multiple cytokines and growth factors. Fibroblast growth factor 1 (FGF-1) is increased in patients with rheumatic arthritis. The aim of this study was to determine whether the expression and secretion of FGF-1 differed in synovial tissue from patients with late stage OA from that in normal tissues. We selected eight patients with late stage OA and eight healthy donors for this study.

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