Oligozoospermia

Copy number variations in spermatogenic failure patients with chromosomal abnormalities and unexplained azoospermia

Y. Dong, Pan, Y., Wang, R., Zhang, Z., Xi, Q., and Liu, R. - Z., Copy number variations in spermatogenic failure patients with chromosomal abnormalities and unexplained azoospermia, vol. 14, pp. 16041-16049, 2015.

Male infertility is mostly caused by spermatogenic failure. Currently, routine genetic analyses of unexplained azoospermia or oligozoospermia are limited to the investigation of Y chromosomal microdeletions and chromosome karyotype analyses. The aim of this study was to find spermatogenic failure genes in patients with chromosomal abnormalities and unexplained azoospermia caused by copy number variations in order to provide a theoretical basis for further research.

Genetic screening and evaluation for chromosomal abnormalities of infertile males in Jilin Province, China

M. Zhang, Fan, H. - T., Zhang, Q. - S., Wang, X. - Y., Yang, X., Tian, W. - J., and Li, R. - W., Genetic screening and evaluation for chromosomal abnormalities of infertile males in Jilin Province, China, vol. 14, pp. 16178-16184, 2015.

Chromosomal abnormality is the most common genetic cause of male infertility, particularly in cases of azoospermia, oligozoospermia, and recurrent spontaneous abortion. Chromosomal rearrangement may interrupt an important gene or exert position effects. The functionality of genes at specific breakpoints, perhaps with a specific role in spermatogenesis, may be altered by such rearrangements. Structural chromosome abnormalities are furthermore known to increase the risk of pregnancy loss.

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