O-naphthoquinone

O-naphthoquinone isolated from Capraria biflora L. induces selective cytotoxicity in tumor cell lines

G. G. Nde S. Wisintainer, Scola, G., Moura, S., Lemos, T. L. G., Pessoa, C., de Moraes, M. O., Souza, L. G. S., Roesch-Ely, M., and Henriques, J. A. P., O-naphthoquinone isolated from Capraria biflora L. induces selective cytotoxicity in tumor cell lines, vol. 14, pp. 17472-17481, 2015.

Biflorin is an o-naphthoquinone isolated from the roots of the plant Capraria biflora L. (Scrophulariaceae). In this study, the cytotoxic effects of biflorin were verified, and late apoptosis was detected in various cancer cell lines by in situ analysis. The cytotoxicity was further evaluated exclusively for 48 h of treatment in different tumor and non-tumor cell lines (Hep-2, HeLa, HT-29, A-375, and A-549, and HEK-293, respectively). The results indicated that biflorin induced selective cytotoxicity in tumor cells.

Subscribe to O-naphthoquinone