Nuclear retention

Cloning and functional identification of a novel BCA3 splice

Y. Zhang, Hu, M. Y., Qiao, C. X., Feng, J. N., Lin, Z., Shen, B. F., Ma, Y. F., Li, Y., Li, Y. L., and Lv, M., Cloning and functional identification of a novel BCA3 splice, vol. 13, pp. 10648-10656, 2014.

The human breast cancer-associated gene (BCA3) was first discovered in breast and prostate cancer cells lines. In vivo studies have shown that BCA3 is mainly expressed in breast tumor cells and not in normal breast and prostate tissues. To date, 3 splice variants of BCA3 have been reported: a double-absent variant lacking exon 3 and exon 5 (BCA3-1), an exon 3-absent variant (BCA3-2), and full-length BCA3.

Subscribe to Nuclear retention