Nuclear magnetic resonance

Metabolic response of LLC xenografted mice to oxythiamine, as measured by [1H] NMR spectroscopy

H. Lu, Lan, W. X., Bo, L., Niu, C., Zhou, J. J., and Zhu, H. L., Metabolic response of LLC xenografted mice to oxythiamine, as measured by [1H] NMR spectroscopy, vol. 14, pp. 11043-11051, 2015.

Oxythiamine (OT) has been proven to be a potential anticancer drug. With the help of NMR-based metabonomics, we studied the metabolic changes within tumor-bearing mice with different levels of OT administration using a C57BL/6 mouse Lewis lung carcinoma tumor transplantation model. We administered different concentrations of OT (75, 150, 300, and 600 mg∙kg-1∙day-1) to the mice orally for 2 weeks, recorded animal weights and tumor volumes, sacrificed the animals, and collected blood and tumor mass samples for nuclear magnetic resonance determination.

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