NSCLC

miR-204 suppresses non-small-cell lung carcinoma (NSCLC) invasion and migration by targeting JAK2

P. Wang, Lv, H. Y., Zhou, D. M., Zhang, E. N., Wang, P., Lv, H. Y., Zhou, D. M., and Zhang, E. N., miR-204 suppresses non-small-cell lung carcinoma (NSCLC) invasion and migration by targeting JAK2, vol. 15, p. -, 2016.

Aberrant expression of microRNA is associated with the development and progression of cancers. MicroRNA-204 (miR-204) down-regulation has been previously demonstrated in non-small-cell lung carcinoma (NSCLC); however, the underlying mechanism by which miR-204 suppresses tumorigenesis in NSCLC remains elusive. In this study, miR-204 expression was found to be down-regulated, and that of Janus kinase 2 (JAK2) was found to be up-regulated in four NSCLC cell lines (A549, H1299, H1650, and H358) compared to the normal lung cell line.

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