Notch signaling

Huwe1 as a therapeutic target for neural injury

J. Zhou, Liu, Q., Mao, M., and Tong, Y., Huwe1 as a therapeutic target for neural injury, vol. 13. pp. 4320-4325, 2014.

The ubiquitin-proteasome system (UPS) regulates many cellular processes, including protein stability, cell cycle control, DNA repair, transcription, signal transduction, and protein trafficking. In fact, UPS plays a key role in various stress conditions such as ischemia, glutamate toxicity, Alzheimer’s disease, and Parkinson’s disease. Huwe1, a homologous to E6-AP carboxy terminus (HECT) domain ubiquitin ligase, is now being regarded as a vital protein involved in neural stem cell differentiation, adult neurogenesis, and the DNA damage response pathway.

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