Non-syndromic cleft of the lip and/or palate

Mutation analysis of PVRL1 in patients with non-syndromic cleft of the lip and/or palate in Guangdong

S. Y. Shu, Zhang, M. J., Cheng, H. Q., Tang, S. J., Chen, W. L., Wu, S. R., Lin, Y., and Chen, Q. S., Mutation analysis of PVRL1 in patients with non-syndromic cleft of the lip and/or palate in Guangdong, vol. 14, pp. 3400-3408, 2015.

Non-syndromic cleft of the lip and/or palate (NSCLP) is a very common birth defect; the poliovirus receptor-like 1 gene (PVRL1) has been identified as a genetic risk factor for NSCLP in patients from Norway, the Philippines, and South America. Given the considerable variation in allele frequencies across these geographical regions, this study explored the relationship between NSCLP and mutations of PVRL1 in patients from Guangdong, China.

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