Non-small cell lung carcinoma

Expression and significance of myeloid differentiation factor 88 in non-small cell lung carcinoma and normal paracancerous tissues

J. Zhu, Li, Q., He, J., and Ma, K., Expression and significance of myeloid differentiation factor 88 in non-small cell lung carcinoma and normal paracancerous tissues, vol. 14, pp. 14239-14245, 2015.

We studied the expression level of myeloid differentiation factor 88 (MyD88) in non-small cell lung carcinoma (NSCLC) and normal paracancerous tissues, to determine its relationship with clinical pathological characteristics and prognosis. In total, 82 NSCLC patients who had received surgical treatment in our hospital between September 2008 and December 2013 were selected for this study. Another 82 normal paracancerous lung tissue samples were used as controls. All patients had complete clinical records, and they were followed-up for 5 years.

Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at-onset of non-small cell lung cancer

W. X. Hu, Ding, C. M., Li, R. J., Fan, H. Y., Guo, Z. J., and Liu, W., Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at-onset of non-small cell lung cancer, vol. 14, pp. 2512-2517, 2015.

The associations between single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) and cancer risk and disease outcome have been extensively analyzed. We investigated the association between age-at-onset and SNPs in the mitochondrial D-loop using a population-based series of non-small cell lung cancer (NSCLC) patients. The D-loop region of mtDNA from NSCLC patients was amplified and sequenced.

Relationship between genetic polymorphisms in MCP-1, CCR-2, and non-small-cell lung cancer in the Han nationality of Northern China

L. Yang, Wang, J., Li, F. - G., Han, M., Chang, X. - J., and Wang, Z. - T., Relationship between genetic polymorphisms in MCP-1, CCR-2, and non-small-cell lung cancer in the Han nationality of Northern China, vol. 14, pp. 3745-3752, 2015.

Lung cancer is a common malignant tumor worldwide and is now the leading cause of cancer-related deaths. Monocyte chemoattractant protein 1 (MCP-1) and its receptor chemokine receptor 2 (CCR-2) are important chemokines. We examined the polymorphisms of 338 unrelated patients with non-small cell lung carcinoma (NSCLC) and 200 unrelated healthy controls of Han nationality in Northern China using polymerase chain reaction-restriction fragment length polymorphism.

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