Non-small cell lung cancer

Associations between clinical characteristics and oncogene expression in patients with non-small cell lung cancer

Y. Han, Yu, D. P., Zhou, S. J., Song, X. Y., Li, Y. S., Xiao, N., Liu, Z. D., Sun, X. J., Zhao, Q. Y., and Liu, S. K., Associations between clinical characteristics and oncogene expression in patients with non-small cell lung cancer, vol. 13, pp. 8913-8924, 2014.

More than 40 oncogenes associated with non-small cell lung cancer (NSCLC) have been identified with varied gene expression. The correlations between specific clinical characteristics and oncogene expression in NSCLC patients were examined. From October 2011 to September 2012, a total of 60 patients with NSCLC (male:female, 34:24; mean age, 59.5 ± 10.6 years; age range, 31-81 years) were diagnosed and evaluated for treatment with radical resection at a single facility.

ERCC1 mRNA expression is associated with the clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy

H. Zhang, Li, J., Zhang, Y., Sun, M., Zhao, P., Zhang, G., Jin, C., Sun, L., He, M., Wang, B., and Zhang, X., ERCC1 mRNA expression is associated with the clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy, vol. 13, pp. 10215-10222, 2014.

We conducted a prospective study to analyze the expression of the excision repair cross-complementing group 1 (ERCC1) and ribonucleotide reductase subunit M1 (RRM1) genes in 297 Chinese patients with advanced non-small cell lung cancer (NSCLC). The goal of this study was to evaluate these genes as potential biomarkers for prediction of tumor response and clinical outcome. Patients with unresectable, locally advanced or metastatic NSCLC were enrolled between September 2007 and September 2009, and they were followed up until September 2012.

The genetic variant rs401681C/T is associated with the risk of non-small cell lung cancer in a Chinese mainland population

H. Wang, Zhao, Y., Ma, J., Zhang, G., Mu, Y., Qi, G., Fang, Z., Wang, L., Fan, Q., and Ma, Z., The genetic variant rs401681C/T is associated with the risk of non-small cell lung cancer in a Chinese mainland population, vol. 12. pp. 67-73, 2013.

Although lung cancer (LC) is a highly environmentally associated disease, genetic factors are also thought to play a role in this disease. In recent years, genome-wide association studies have identified various susceptible genetic regions for LC. Herein, we used high-resolution melting analysis to genotype 2 significant single nucleotide polymorphisms previously reported in Caucasians, that is, rs401681 at 5p15.33 and rs8034191 at 15q25, in a case-control study with 492 LC cases and 486 cancer-free controls in a Chinese population.

Association between survivin gene promoter -31G/C and -644C/T polymorphisms and non-small cell lung cancer

E. Aynaci, Coskunpinar, E., Eren, A., Kum, O., Oltulu, Y. M., Akkaya, N., Turna, A., Yaylim, I., and Yildiz, P., Association between survivin gene promoter -31G/C and -644C/T polymorphisms and non-small cell lung cancer, vol. 12, pp. 3975-3982, 2013.

Lung cancer is the most common cancer worldwide. Survivin is one of the first reported inhibitors of apoptosis proteins, which is an important family of proteins that regulate apoptosis. The survivin gene is located on human chromosome 17q25, which is composed of 142 amino acids. A common polymorphism of the survivin gene promoter -31G/C has been shown to influence cancer risk. This genetic variant has been associated with overexpression of survivin at both protein and mRNA levels in cancer cells.

STAT3 gene polymorphisms and susceptibility to non-small cell lung cancer

B. Jiang, Zhu, Z. Z., Liu, F., Yang, L. J., Zhang, W. Y., Yuan, H. H., Wang, J. G., Hu, X. H., and Huang, G., STAT3 gene polymorphisms and susceptibility to non-small cell lung cancer, vol. 10, pp. 1856-1865, 2011.

Signal transducer and activator of transcription protein 3 (STAT3) has been implicated in cancer development and is recognized as a type of oncogene. However, association studies of single nucleotide polymorphisms (SNPs) in the STAT3 gene with cancer risk are rare and not available for lung cancer. We examined whether STAT3 polymorphisms are associated with the risk of non-small cell lung cancer (NSCLC). Eight SNPs in the STAT3 gene were genotyped by TaqMan assays in 326 NSCLC cases and 432 controls in a Chinese population.

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