Nitric oxide synthase 3

Association between functional polymorphisms in the nitric oxide synthase 3 gene and pediatric acute respiratory distress syndrome

L. Wei, An, Y., Wang, J., Wei, L., An, Y., and Wang, J., Association between functional polymorphisms in the nitric oxide synthase 3 gene and pediatric acute respiratory distress syndrome, vol. 15, p. -, 2016.

Nitric oxide mediates multiple physiological functions, including neurotransmission, immune regulation, angiogenesis, antiplatelet activity, and surfactant maturation or secretion. Mice deficient in the nitric oxide synthase 3 (NOS3) gene displayed defective lung vascular development and fatal respiratory distress. Polymorphisms in NOS3 have been reported to be associated with respiratory distress syndrome (RDS).

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