Nexilin

Hepatocyte growth factor upregulates nexilin gene expression in cardiomyocytes via JNK pathway

C. Wang, You, X., Jiang, C., Jin, C., Meng, X., and Ding, D., Hepatocyte growth factor upregulates nexilin gene expression in cardiomyocytes via JNK pathway, vol. 13, pp. 4976-4982, 2014.

Hepatocyte growth factor (HGF) is a protective factor in myocardial injury, but its mechanisms of action have not yet been fully elucidated. Nexilin, which locates specifically to the Z-disc, is a novel Z-disc protein that enables the Z-discs to persistently withstand the extreme mechanical forces generated during muscle contraction. Therefore, we investigated the role of HGF in modulating nexilin expression in hypoxia-reoxygenation (H/R)-treated cardiomyocytes. We cultured neonatal cardiomyocytes and treated them with HGF.

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