Hepatocyte growth factor upregulates nexilin gene expression in cardiomyocytes via JNK pathway
“Hepatocyte growth factor upregulates nexilin gene expression in cardiomyocytes via JNK pathway”, vol. 13, pp. 4976-4982, 2014.
, Hepatocyte growth factor (HGF) is a protective factor in myocardial injury, but its mechanisms of action have not yet been fully elucidated. Nexilin, which locates specifically to the Z-disc, is a novel Z-disc protein that enables the Z-discs to persistently withstand the extreme mechanical forces generated during muscle contraction. Therefore, we investigated the role of HGF in modulating nexilin expression in hypoxia-reoxygenation (H/R)-treated cardiomyocytes. We cultured neonatal cardiomyocytes and treated them with HGF.