Pdxl and its role in activating Ngn3 and Pax6 to induce differentiation of iPSCs into islet β cells
“Pdxl and its role in activating Ngn3 and Pax6 to induce differentiation of iPSCs into islet β cells”, vol. 14, pp. 8892-8900, 2015.
, The pancreatic and duodenal homeobox factor 1 (Pdx1) protein is the most pivotal transcription factor in the development of islet β cells. This study investigated the role of Pdx1 and its mechanism in differentiating induced pluripotent stem cells (iPSCs) into islet β cells. iPSCs derived from human skin fibroblasts were cultured in vitro and directionally induced to differentiate for 20 days.