Neural stem cells

Effect of neural stem cell transplantation combined with erythropoietin injection on axon regeneration in adult rats with transected spinal cord injury

Y. Zhao, Zuo, Y., Wang, X. L., Huo, H. J., Jiang, J. M., Yan, H. B., and Xiao, Y. L., Effect of neural stem cell transplantation combined with erythropoietin injection on axon regeneration in adult rats with transected spinal cord injury, vol. 14, pp. 17799-17808, 2015.

We investigated the effect of neural stem cells (NSC) and erythropoietin (EPO) on axon regeneration in adult rats with transected spinal cord injury, and provided an experimental basis for clinical treatment. Forty Wistar rats with T10-transected spinal cord injury were randomly divided into four groups of ten rats: a control group (group A), an NSC-transplant group (group B), an NSC-transplant and EPO group (group C), and an EPO group (group D).

Huwe1 as a therapeutic target for neural injury

J. Zhou, Liu, Q., Mao, M., and Tong, Y., Huwe1 as a therapeutic target for neural injury, vol. 13. pp. 4320-4325, 2014.

The ubiquitin-proteasome system (UPS) regulates many cellular processes, including protein stability, cell cycle control, DNA repair, transcription, signal transduction, and protein trafficking. In fact, UPS plays a key role in various stress conditions such as ischemia, glutamate toxicity, Alzheimer’s disease, and Parkinson’s disease. Huwe1, a homologous to E6-AP carboxy terminus (HECT) domain ubiquitin ligase, is now being regarded as a vital protein involved in neural stem cell differentiation, adult neurogenesis, and the DNA damage response pathway.

Influence of neural stem cell transplantation on angiogenesis in rats with spinal cord injury

Z. Li, Guo, G. - H., Wang, G. - S., Guan, C. - X., and Yue, L., Influence of neural stem cell transplantation on angiogenesis in rats with spinal cord injury, vol. 13, pp. 6083-6092, 2014.

We examined the influence of neural stem cell transplantation on angiogenesis in rats with spinal cord injury. Sixty rats with spinal cord injury were divided into an experimental group and a control group and given neural stem cells or an equivalent amount of phosphate-buffered saline by intravenous transplantation, respectively.

Differentiation of neonatal dorsal root ganglion-derived neural stem cells into oligodendrocytes after intrathecal transplantation into a cauda equina lesion model

Z. Y. Fu, Shi, J. G., Liu, N., Jia, L. S., Yuan, W., and Wang, Y., Differentiation of neonatal dorsal root ganglion-derived neural stem cells into oligodendrocytes after intrathecal transplantation into a cauda equina lesion model, vol. 12, pp. 6092-6102, 2013.

Cauda equina syndrome (CES) is characterized by varying patterns of low back pain, sciatica, lower extremity sensorimotor loss, and bowel and bladder dysfunction. The prognosis for complete recovery of CES is dependent on not only the time before surgical intervention with decompression but also the severity of the nerve damage. Delayed or severe nerve compression impairs the capability of nerve regeneration. Transplantation of neural stem cells (NSCs) may facilitate axon regeneration and functional recovery in a spectrum of neurological disorders.

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