Nerve growth factor

Tetradecyl 2,3-dihydroxybenzoate promotes functional recovery after spinal cord injury in adult rats

Y. M. Ding, Zhu, J. Y., Zhang, S. J., Zhang, S. S., Wang, C., Wang, L. L., Zhang, X., Ding, Y. M., Zhu, J. Y., Zhang, S. J., Zhang, S. S., Wang, C., Wang, L. L., and Zhang, X., “Tetradecyl 2,3-dihydroxybenzoate promotes functional recovery after spinal cord injury in adult rats”, vol. 15, p. -, 2016.

Tetradecyl 2,3-dihydroxybenzoate (ABG001) is a small molecule separated from gentian extract that has a similar effect to nerve growth factor. It is not clear whether it can promote functional recovery in animals suffering from a central nervous system injury. In order to explore the role of ABG001 in restoration of tissue structure and motor function of rats with spinal cord injury (SCI), ABG001 (0.4 mg/kg) was administered intraperitoneally.

Characteristic element of matrix attachment region mediates vector attachment and enhances nerve growth factor expression in Chinese hamster ovary cells

X. Y. Wang, Zhang, J. H., Sun, Q. L., Yao, Z. Y., Deng, B. G., Guo, W. Y., Wang, L., Dong, W. H., Wang, F., Zhao, C. P., and Wang, T. Y., “Characteristic element of matrix attachment region mediates vector attachment and enhances nerve growth factor expression in Chinese hamster ovary cells”, vol. 14, pp. 9191-9199, 2015.

Preliminary studies have suggested that a characteristic element of the matrix attachment region (MAR) in human interferon-β mediates the adhesion of vectors to Chinese hamster ovary (CHO) cells. In this study, we investigated if vector adhesion increased nerve growth factor (NGF) expression in CHO cells. The MAR characteristic element sequence of human interferon-β was inserted into the multiple-cloning site of the pEGFP-C1 vector. The target NGF gene was inserted upstream of the MAR characteristic element sequence to construct the MAR/NGF expression vector.

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