Nasopharyngeal carcinoma

Nuclear magnetic resonance-based study reveals the metabolomics profile of nasopharyngeal carcinoma

Y. Wang, Luo, X., Zhang, G. H., Li, S. L., Wang, Y., Luo, X., Zhang, G. H., and Li, S. L., Nuclear magnetic resonance-based study reveals the metabolomics profile of nasopharyngeal carcinoma, vol. 15, p. -, 2016.

Proton nuclear magnetic resonance ([1H]-NMR) spectroscopy has been used to investigate metabolites in serum and several types of tissue. We used NMR spectroscopy to explore the differential metabolic profiles in serum from nasopharyngeal carcinoma (NPC) patients. Moreover, metabolites with potential as biomarkers for identifying NPC patients were primarily identified. Serum samples were collected from 40 enrolled participants comprising 20 healthy subjects and 20 NPC patients. Samples were analyzed using a 600-MHz NMR spectrometer.

Expression of Epstein-Barr virus antibodies EA-IgG, Rta-IgG, and VCA-IgA in nasopharyngeal carcinoma and their use in a combined diagnostic assay

Y. Li, Wang, K., .K.Yin, S., Zheng, H. L., Min, D. L., Li, Y., Wang, K., .K.Yin, S., Zheng, H. L., Min, D. L., Li, Y., Wang, K., .K.Yin, S., Zheng, H. L., and Min, D. L., Expression of Epstein-Barr virus antibodies EA-IgG, Rta-IgG, and VCA-IgA in nasopharyngeal carcinoma and their use in a combined diagnostic assay, vol. 15, p. -, 2016.

Epstein-Barr virus (EBV) infection is closely associated with nasopharyngeal carcinoma, which can be monitored by the levels of Rta protein antibody IgG (Rta-IgG), early antigen antibody (EA-IgG), and viral capsid antibody (VCA-IgA). In the present study, we investigated the serum levels of Rta-IgG, EA-IgG, and VCA-IgA in nasopharyngeal cancer patients, and the diagnostic value of a combined assay that includes these antibodies in addition to the EBV-DNA.

Expression and clinical significance of LRRC4 in benign and malignant nasopharyngeal diseases

X. - J. Zhou, Wang, Y., Zhang, L. - J., and Chen, J. - H., Expression and clinical significance of LRRC4 in benign and malignant nasopharyngeal diseases, vol. 14, pp. 16403-16409, 2015.

The aim of this study was to investigate the expression of LRRC4 in nasopharyngeal carcinomas, nasopharyngeal precancerous lesions, and nasopharyngitis as well as the clinical significance of LRRC4. Fifty patients with nasopharyngeal carcinoma were selected as study subjects; 28 patients with chronic nasopharyngitis and 22 patients with nasopharyngeal precancerous lesions served as controls.

Expression of GRIN2A in benign and malignant nasopharyngeal diseases and its clinical significance

X. J. Zhou, Lin, B. R., and Wang, Y., Expression of GRIN2A in benign and malignant nasopharyngeal diseases and its clinical significance, vol. 14, pp. 17289-17295, 2015.

The gene glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A) is associated with development and neuron viability, and our previous studies showed it to be substantially methylated in nasopharyngeal carcinoma, indicating a link to this disease. The aim of this work was to investigate GRIN2A expression and its clinical significance in nasopharyngeal carcinoma, in contrast to nasopharyngitis and nasopharyngeal precancerous lesions.

Interleukin-10 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis

Y. - F. Yu, Han, Z. - G., Guo, W. - B., Zhang, G. - J., Yang, J. - K., Wu, F. - L., Ou, Q. - Y., Li, Y. - H., Cai, X. - Y., Zhan, Z. - N., Chen, J. - H., Xie, W. - L., Tang, L., and Liu, C. - D., Interleukin-10 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis, vol. 14, pp. 18945-18957, 2015.

It has been reported that interleukin-10 (IL-10) promoter genes (1082 A/G, 819 T/C, 592 A/C) are associated with nasopharyngeal carcinoma (NPC). However, the results remain controversial and ambiguous. To resolve inconsistencies in published data, we performed a meta-analysis to ascertain the association between IL-10 polymorphisms and NPC risk. Two case-control studies and two cohort studies were quantitatively analyzed to evaluate IL-10 promoter gene polymorphisms and NPC risk.

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